Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Motor neurons reach from the brain to the spinal cord and from the spinal cord to the muscles throughout the body. The progressive degeneration—or loss of function—of the motor neurons in ALS eventually leads to their death. When the motor neurons die, the ability of the brain to start and control muscle movement is lost.
Sporadic ALS is the most common type of ALS, and it affects approximately 90% to 95% of all people living with ALS. It is called “sporadic” because it can affect anyone and there is no clear cause. Although the majority of patients suffer from sporadic ALS, a smaller fraction of patients have an inherited, or familial, form of ALS caused by a variety of genetic mutations.
This type of the disease is usually genetic, and is inherited from a family member. SOD1-ALS affects approximately 2% of all people living with ALS. It is caused by a mutation, or change, to a gene called superoxide dismutase 1, or SOD1. This clinical trial includes people who are living with ALS caused by a SOD1 gene mutation.
The VALOR Study is evaluating a potential new treatment for people living with ALS caused by a SOD1 gene mutation. Click below to take our online questionnaire and see if you may be eligible to participate.Am I Eligible?